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Joseph Eastman's avatar

Thank you so much for the study. LP.8.1 is getting a lot of press, HA! I had not seen this yet so I will give this a read this evening. It will be interesting to see where LP.8.1* and XEC.4 are sitting tomorrow when the variant proportions are updated.

Again, thank you for you input.

Joe

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Glorfindel's avatar

Watch Pennsylvania.

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Joseph Eastman's avatar

Thank you for the frame! Let me look into this link. I know others have successfully grabbed it. I will let you know.

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Glorfindel's avatar

Dr. Eastman...Interesting post as always. A couple of questions...with your current prediction, it looks like the upcoming trough to peak is only about 2 months. Am I reading that right? Are we seeing time compression for trough to peak as opposed to earlier in the pandemic? Definitely might be saying something.

Is it your intention to SEPARATE the various pathogens on separate graphs? Might get a little confusing if everything is on one graph.

Not that you don't have enough to do, but human metapneumonia virus seems to be on the increase nationally, if from low levels.

I guess you might have entitled this post, "Beware of the Ides of March"

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Veni vidi vici's avatar

How is the current Covid booster vaccine doing with the new variants LP.8.1. I have not seen any recent studies addressing this and I would be very surprised to see any more covid vaccines boosters Rec’s coming out of the FDA. I am concerned about taking boosters that are no longer well targeted to the variants and risk OAS. Any ideas of how to keep abreast of this situation?

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Glorfindel's avatar

A second furin cleavage site?

"Interestingly, the two variants are distinguished by a single mutation, K679R, which generates a new furin consensus motif in the LP.8.1.1 S protein, overlapping the original furin motif located at the border between the S1 and S2 subunits (appendix p 2).

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2825%2900113-6/fulltext

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Rod Stasick 🇨🇦's avatar

Thanks for the update as always. Couldn't get the individual states to show, but maybe next time. I framed my profile picture. Thanks again!

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